2013 Fiscal Year Final Research Report

The imaging study of sigma-1 receptor in the brain for the objective evaluation method of the disease caused by aging or stress

Research Project

Project/Area Number	23791400
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Kanazawa University
Principal Investigator	KOZAKA Takashi 金沢大学, 学際科学実験センター, 助教 (50579836)
Project Period (FY)	2011 – 2013
Keywords	σ-2受容体 / ベサミコール
Research Abstract	For the purpose of the development of the objective evaluation method of the disease caused by aging or stress, I worked on the imaging study of the sigma-1 receptor in the brain. Out of my expectation, the newly developed compound, p-iodo-trans-decalinvesamicol (PIDV), was found to possess the high affinity and selectivity to sigma-2 receptor, not to sigma-1 receptor, in in vitro. The sigma-2 receptor is known to express in higher density in high proliferation potency human cancer cells, such as breast cancer. However, the clinically applicable sigma-2 receptor ligand is not developed yet. As a result of this study, I succeeded in developing the promising sigma-2 receptor imaging agent which enables the early image diagnosis of breast cancer.