2012 Fiscal Year Final Research Report
Development of Novel Prostate Specific Membrane Antigen Targeting Probes for Prostate Cancer Imaging
| Project/Area Number |
23791413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KIMURA Hiroyuki 京都大学, 放射性同位元素総合センター, 助教 (50437240)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射性医薬品 / 造影剤 / 前立腺癌 |
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| Research Abstract |
PCa (prostate cancer) is the most commonly diagnosed and the second leading cause of cancer-related deaths in men in the world. So, non-invasive diagnoses of PCa by imaging techniques have high clinical benefit. PSMA (Prostate Specific Membrane Antigen) is a noticeable target for PCa imaging. Ten~1,000-fold higher expression of PSMA have been reported in PCa than in normal prostate. Therefore, we started the research for developing novel PSMA imaging probes.[123I]IGLCE showed high stability, high affinity for PSMA, PSMA-specific high tumor uptake, and fast blood clearance. In the SPECT/CT study, [123I]IGLCE clearly distinguishedLNCaP tumors from PC-3 tumors. These results suggest that [123I]IGLCE can be a promising probe for PSMA imaging in future.
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