2012 Fiscal Year Final Research Report
Software development and three-dimensional quantitative analysis to establish multidisciplinary diagnosis for pulmonary adenocarcinoma
| Project/Area Number |
23791417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肺腺癌 / 病理学的国際分類 / 病理学的浸潤部 / 病理学的非浸潤部 / すりガラス成分 / 3 次元画像解析 |
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| Research Abstract |
A custom-developed software can segment solid portion and ground-glass opacity (GGO) using the previously-reported threshold selection method for segmenting gray-level images, and can eliminate vessels on CT using 3-dimensionalmulti-scale line filter for segmentation and visualization of curvilinear structures such as vessels, resulting in calculating a rate of pure solid portion volume to whole tumor volume (%Solid) regardless of distribution of solid portions in nodule. Three-dimensional %Solid of adenocarcinomas is feasible for estimating prognosis. Nodule with %Solid>=63% significantly contributed to short overall and disease-free survival.
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