2012 Fiscal Year Final Research Report
A basic research of synchrotron microbeam radiation therapy forradiation resistant malignant tumors
| Project/Area Number |
23791424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射光 / 格子状照射 / マイクロビーム / 放射線治療 |
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| Research Abstract |
Synchrotron microbeam radiation therapy（SMRT) permits the delivery of very high radiation doses to the tumors in a single fraction. In this study, we have challenged to evaluate normal tissue tolerance and mortality by SMRT to the brain of the mice with comparing to broad beam irradiation. Our results including histopathological findings, immunohistologic analysis and functional analysis indicated that the SMRT enables to deliver extremely high doses without loss of normal tissue function.
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[Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index2012
Author(s)
Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
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Journal Title
Radiat Oncol
Volume: 7
Pages: 104
DOI
Peer Reviewed
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[Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy2012
Author(s)
Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T, Sugimura K
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82
Pages: 1509-1514
DOI
Peer Reviewed
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