2014 Fiscal Year Final Research Report
Project/Area Number |
23791442
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Saitama Medical University |
Principal Investigator |
INOUE Tsutomu 埼玉医科大学, 医学部, 准教授 (30406475)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Keywords | 慢性腎臓病 / 虚血 / 線維化 / MRI / BOLD / DWI / ASL |
Outline of Final Research Achievements |
Chronic kidney disease (CKD) is characterized by tubular atrophy and interstitial fibrosis. These pathological changes are caused by decreased renal oxygenation, which initiates and promotes a fibrotic response. Therefore, an evaluation of the degree of fibrosis/hypoxia and renal blood flow in CKD patients is beneficial for the determination of the prognosis of CKD. For the evaluation of CKD patients in this study, we employed (1) blood oxygen level-dependent magnetic resonance imaging (MRI) for the noninvasive assessment of tissue oxygen bioavailability, (2) diffusion-weighted MRI for the measurement of the apparent diffusion coefficients reflecting the degree of interstitial fibrosis, and (3) arterial spin labeling for the noninvasive measurement of tissue perfusion. We believe that this method will play a significant role in drug development as it can evaluate changes in the physical condition of the kidney prior to changes in serum creatinine and proteinuria.
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Free Research Field |
腎臓内科学
|