Establishment of chemo-brachytherapy using seed sources

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791443
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: OHASHI Toshio 慶應義塾大学, 医学部, 講師 (70327641)
• Project Period (FY): 2011 – 2012
• Keywords: 前立腺癌 / 小線源治療 / 治療効果 / シード

Research Abstract

It is essential to expand the efficient treatment ranges and escalate treatment intensity by the means of brachytherapy-based multi-modality approach for the intermediate to high-risk prostate cancer. As a result of dose calculation modeling and verificat

Research Products

• [Journal Article] Comparison of preplanning and intraoperativeplanning for I-125 prostate brachytherapy (2013)
  • Author(s): Kayo Yoshida, Toshio Ohashi, AtsunoriYorozu, Kazuhito Toya, Toru Nishiyama,Shiro Saito, Takashi Hanada, YutakaShiraishi, Naoyuki Shigematsu
  • Journal Title: Jpn J Clin Oncol Volume: 43 Pages: 83-389
  • DOI: DOI:10.1093/jjco/hys240
  • Peer Reviewed
• [Journal Article] 前立腺癌術後PSA再発に対する救済放射線治療の成績 (2012)
  • Author(s): 酒寄正範, 大橋俊夫, 深田淳一, 白石悠, 花田剛士, 茂松直之
  • Journal Title: 臨床放射線 Volume: 57 Pages: 1193-1199
  • Peer Reviewed
• [Journal Article] Impact of MRI-based Postimplant Dosimetric Assessment in Prostate Brachytherapy using Contrast-Enhanced T1 Weighted Images. (2012)
  • Author(s): Toshio Ohashi, Tetsuo Momma, ShojiYamashita, Katsumi Nagatsuma, KunimitsuKanai, Kazuhito Kitagawa, ShinichiTakahashi, Takashi Hanada, AtsunoriYorozu, Naoyuki Shigematsu
  • Journal Title: Brachytherapy Volume: 11 Pages: 468-475
  • DOI: DOI:10.1016/j.brachy.2011.12.010
  • Peer Reviewed
• [Journal Article] Predicting pubic arch interference in prostate brachytherapy on transrectal ultrasonography-computed tomographyfusion images. (2012)
  • Author(s): Junichi Fukada, Naoyuki Shigematsu,Jun Nakashima, Toshio Ohashi, OsamuKawaguchi, Mototsugu Oya
  • Journal Title: J Radiat Res Volume: 53 Pages: 753-759
  • DOI: DOI:10.1093/jrr/rrs020
  • Peer Reviewed
• [Journal Article] Dose Constraint for Minimizing Grade 2+ Rectal Bleeding following Brachytherapy combined with External Beam Radiotherapy for Localized Prostate Cancer: Rectal Dose-Volume Histogram Analysis of 457 Patients (2011)
  • Author(s): Yutaka Shiraishi, Atsunori Yorozu,Toshio Ohashi, Kazuhito Toya, Satoshi Seki,Kayo Yoshida, Tomoya Kaneda, Shiro Saito,Toru Nishiyama, Takashi Hanada, Naoyuki Shigematsu
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81 Pages: e127-133
  • Peer Reviewed
• [Journal Article] The effect of tissue composition of the prostate on thedose calculation for 125I brachytherapy (2011)
  • Author(s): Takashi Hanada, Atsunori Yorozu,Toshio Ohashi, Naoyuki Shigematsu, KyokoSaito, Koichi Maruyama.
  • Journal Title: Kitasato Med J Volume: 41 Pages: 136-144
  • Peer Reviewed
• [Presentation] Japanese nationwidemulti-institutional cohort study of prostate cancer brachytherapy with permanent seed implantation (2013)
  • Author(s): Saito S, Ito K, Yorozu A, Aoki M, KogaH, Satoh T, Ohashi T, Shigematsu N, DaimonT, Kojima S, Dokiya T, Fukushima M, Yamanaka H
  • Organizer: he 2013 ASCO Annual Meeting
  • Place of Presentation: シカゴ,アメリカ
  • Year and Date: 2013-05-31
• [Presentation] 前立腺がん密封小線源治療について - 放射線科医の立場から - (2012)
  • Author(s): 大橋俊夫
  • Organizer: 第2回山梨大学小線源治療講演会
  • Place of Presentation: 山梨
  • Year and Date: 2012-12-20
• [Presentation] Optimal Acquisition Parameter Selection for CT Simulators Reducing Seed Artifacts in Permanent Seed Implants. (2012)
  • Author(s): Toshio Ohashi, Shinichi Takahashi,Takashi Hanada, Yusuke Watanabe,Toshihiro Ishihara, Kazuhito Kitagawa,Shoji Yamashita, Tetsuo Momma, Masami Moriyama.
  • Organizer: 54th American Society for Therapeutic Radiology and Oncology Annual Meeting
  • Place of Presentation: ボストン,アメリカ
  • Year and Date: 2012-11-29
• [Presentation] Assessment of late rectal toxicity after I-125 prostate brachytherapy using equivalent uniform dose. (2012)
  • Author(s): Yutaka Shiraishi, Takashi Hanada, Toshio Ohashi, Junichi Fukada, Atsunori Yorozu, Naoyuki Shigematsu
  • Organizer: 54th American Society for Therapeutic Radiology and Oncology Annual Meeting
  • Place of Presentation: ボストン,アメリカ
  • Year and Date: 2012-11-29
• [Presentation] Variation of rectal volume sand dosimetry values including NTCP due to inter-fractional variability receiving 2Dbased IG-IMRT for prostate cancer (2012)
  • Author(s): Takashi Hanada, Yutaka Shiraishi, Toshio Ohashi, Junichi Fukada, Naoyuki Shigematsu.
  • Organizer: 54th American Society for Therapeutic Radiology and Oncology Annual Meeting
  • Place of Presentation: ボストン,アメリカ
  • Year and Date: 2012-11-29
• [Presentation] ExacTracSystemを用いたシード線源マッチングの有用性 (2012)
  • Author(s): 仁科亮平,江里口貴久,大橋俊夫,奥 洋平,大岡義一,青木陽介,下内欣亮,野村一弘,片山夏美,武田篤也
  • Organizer: 第25回日本放射線腫瘍学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-23
• [Presentation] 3DCRT, IMRT, I-125シード治療のBED, EUDの計算に対する基礎的検討. (2012)
  • Author(s): 花田剛士,萬 篤憲,白石 悠,大橋俊夫,茂松直之
  • Organizer: 第25回日本放射線腫瘍学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-23
• [Presentation] 直腸体積変化が前立腺癌シード治療ポストプランにあたえる影響. (2012)
  • Author(s): 大橋俊夫,渡邊有輔,山下昌次,門間哲雄,花田剛士,萬 篤憲,茂松直之
  • Organizer: 第25回日本放射線腫瘍学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-23
• [Presentation] ケロイド術後電子線照射の治療成績 (2012)
  • Author(s): 大橋俊夫
  • Organizer: 第4回日本創傷外科学会 総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-27
• [Presentation] ファントムを用いたI-125シード治療ポストプランCTの撮影最適条件の検討 (2012)
  • Author(s): 高橋真一,渡邊有輔,大橋俊夫,花田剛士,石原敏裕,山下昌次,門間哲雄,森山正己
  • Organizer: 第14回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 長野
  • Year and Date: 2012-05-25
• [Presentation] 前立腺癌シード治療 Uniform Doseを用いた晩期直腸有害事象の評価 (2012)
  • Author(s): 白石悠,花田剛士,大橋俊夫,戸矢和仁,萬篤憲,斉藤史郎,茂松直之
  • Organizer: 第14回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 長野
  • Year and Date: 2012-05-25
• [Presentation] I-125小線源治療後12および24ヶ月目にPSA高値を呈する症例の検討 (2012)
  • Author(s): 門間哲雄,金井邦光,長妻克己,大橋俊夫,山下昌次
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2012-04-23
• [Presentation] 研修医セミナー 放射線治療 「こんなによく効く放射線治療」 (2012)
  • Author(s): 大橋俊夫
  • Organizer: 第71回医学放射線学会総会・学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2012-04-15
• [Presentation] エキスパートから学ぶリアルタイムによる辺縁配置法のポイント (2012)
  • Author(s): 大橋俊夫
  • Organizer: 第1回前立腺癌シード療法コンセンサス会議
  • Place of Presentation: 東京
  • Year and Date: 2012-02-02
• [Presentation] 体位変換による前立腺癌シード治療術後計算の変化 (2011)
  • Author(s): 大橋俊夫,山下昌次,門間哲雄,花田剛士,深田淳一,茂松直之
  • Organizer: 第24回日本放射線腫瘍学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-18
• [Presentation] 外照射用治療計画装置によるI-125シード治療の術後線量計算の精度 (2011)
  • Author(s): 花田剛士,萬篤憲,大橋俊夫,茂松直之
  • Organizer: 第24回日本放射線腫瘍学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-18
• [Presentation] 骨照合での前立腺癌IMRT におけるinterfractional variabilityの検討 (2011)
  • Author(s): 白石悠,大橋俊夫,花田剛士,深田淳一,関智史,菅原章友,川口修,茂松直之
  • Organizer: 第24回日本放射線腫瘍学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-17
• [Presentation] 前立腺癌に対するIMRTの当院における初期治療経験 (2011)
  • Author(s): 長田浩彦,大橋俊夫,菅原章友,水野隆一,菊地栄次,宮嶋哲,陣崎雅弘,中川 健,茂松直之,大家基嗣
  • Organizer: 第7回泌尿器腫瘍放射線(GUTR)研究会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-29
• [Presentation] 前立腺癌術後PSA再発に対する救済放射線治療の成績 (2011)
  • Author(s): 酒寄正範,大橋俊夫, 深田淳一,白石悠,花田剛士,茂松直之
  • Organizer: 第49回日本癌治療学会総会学術集会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-28
• [Presentation] Evaluation of dosimetric parameter dependence due to the effect of tissue composition of the prostate on the dose calculation for 125I brachytherapy (2011)
  • Author(s): Takashi Hanada, Atsunori Yorozu,Toshio Ohashi, Yutaka Shiraishi, Junichi Fukada, Naoyuki Shigematsu, Koichi Maruyama.
  • Organizer: The 6th Japan-Korean Joint Meeting on Medical Physics
  • Place of Presentation: 福岡
  • Year and Date: 2011-09-10
• [Presentation] 治療技術のコツと落とし穴:前立腺LDR (2011)
  • Author(s): 大橋俊夫
  • Organizer: 第13回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-14
• [Presentation] I-125シード治療のTRUSキャリブレーションQA精度による線量誤差 (2011)
  • Author(s): 高橋真一,北川一仁,藤吉真沙也,大橋俊夫,花田剛士,山下昌次,門間哲雄,森山正己
  • Organizer: 第13回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-13
• [Presentation] 外部照射併用125Iシード治療のマルチモダリティ線量評価法 (2011)
  • Author(s): 花田剛士,萬篤憲,大橋俊夫,茂松直之
  • Organizer: 第13回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-13
• [Presentation] Impact of PosturalChanges in Postimplant DosimetricAnalysis for I-125 Prostate Brachytherapy (2011)
  • Author(s): Toshio Ohashi, Tetsuo Momma, ShojiYamashita, Takashi Hanada, Junichi Fukada,Naoyuki Shigematsu.
  • Organizer: ESTRO 30th Anniversary Congress
  • Place of Presentation: ロンドン,イギリス
  • Year and Date: 2011-05-10
• [Presentation] Outcome after I-125 brachytherapy combined with external beam radiotherapy for high-risk prostate cancer (2011)
  • Author(s): Yutaka Shiraishi, Atsunori Yorozu, Toshio Ohashi, Kazuhito Toya, Kayo Yoshida,Tomoya Kaneda, Shiro Saito, Toru Nishiyama,Takashi Hanada, Naoyuki Shigematsu
  • Organizer: ESTRO 30thAnniversary Congress.
  • Place of Presentation: ロンドン,イギリス
  • Year and Date: 2011-05-10