2014 Fiscal Year Final Research Report
Myocardial imaging of radiolabeled anti HIF-1 antibody in infarct rat
| Project/Area Number |
23791452
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 心臓核医学 / 心筋梗塞 / 小動物 |
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| Outline of Final Research Achievements |
The feasibility of myocardial imaging of radiolabeled anti HIF-1 antibidy was evaluated. In acute infarction model, significant uptake signal from infarct myocardium was observed, but in chronic myocardial infarction model, myocardial imaging was not detectable. Anti HIF-1 imaging was thought to feasible in acute phase, but not in chronic phase. We also performed comparison study for total occlusion and re-perfusion model. There was significant myocardial signal uptake in re-perfusion model, but not in total occlusion model.
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| Free Research Field |
イメージング
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