2013 Fiscal Year Final Research Report
Development of new photon activation therapy with use of parametric X-ray
| Project/Area Number |
23791453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 光線力学療法 / パラメトリックX線照射 |
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| Research Abstract |
The parametric X-ray radiation can use at LEBRA, Nihon University. The silicon crystal has been used as a radiation source. However, higher energy PXR is necessary for the future clinical application as medical images or treatments. We hypothesized that the use of diamond crystal as a radiation source could be useful for higher energy. As the results, tunable PXR beam from the diamond crystal was successfully observed and X-ray imaging was carried out using the PXR beam up to 60 keV.
124I-HPPH has been developed for photodynamic therapy. We hypothesize that HPPH with cold iodine (1276I-HPPH, 717), which occurs as an intermediate product in 124I-HPPH synthesis, can act as a new specific and selective radiosensitizer, because iodine is used as a contrast agent in clinical X-ray imaging. In this study, we evaluated the radiosentizing activity of 717 in a human bladder cancer cell line (T24). We revealed that Utilization of 717 has a advantages as a radio sensitizer.
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[Journal Article] AN IODINE LABELED PORPHYRIN AS A NEW RADIATION SENSITIZER IN HUMAN BLADDER CANCER CELLS IN VITRO AND IN VIVO, COMBINATING PHOTODYNAMIC THERAPY (PDT) AND PHOTON ACTIVATION THERAPY (PAT)2013
Author(s)
Ishibashi N, Fujiwara K, Pandey K R, Kataba M, Oguni A, Igarashi J, Soma M, Shizukuishi T, Maebayashi T, Abe K, Abe O, Takahashi M and Tanaka Y.
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Journal Title
Journal of Nihon University Medical Association
Volume: 72(4)
Pages: 212-219
Peer Reviewed
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