2012 Fiscal Year Final Research Report
The elucidation of chronic inflammation by IL-23/Th17 and the application to cancer immunotherapy
| Project/Area Number |
23791482
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUSHITA Marimo (SATO Marimo) 東京大学, 医科学研究所, 助教 (50401253)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 実験外科学 |
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| Research Abstract |
Th1 cells and Th17 cells were significantly enhanced by systemic administration of IL-23. However, it is still unknown about the effects of Th17 cells in antitumor immunity. Th17 cells promote an IL-17 production through IL-23 which a macrophage and dendritic cells produce by antigen stimulation in chronic inflammation. In this project, I have found the mechanisms of the antitumor effects of Th17 cells by systemicadministration of IL-23 using wild-type and IL-17 knockout mouse.
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