2012 Fiscal Year Final Research Report
Can hypoxic preconditioning enhance angiogenic potency of bone marrow cells?
| Project/Area Number |
23791487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Okayama University (2012)
Yamaguchi University (2011) |
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Principal Investigator |
KUBO Masayuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60420519)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管再生 / プレコンディショニング / 低酸素 / 骨髄細胞 / 再生医療 / 加齢 / 幹細胞 / 酸化ストレス |
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| Research Abstract |
We have demonstrated that ex vivohypoxic preconditioning of bone marrow cells from young healthy individuals can enhance their potency for inducing therapeutic angiogenesis. However, considering that advanced aged and systemic disease such as diabetes could contribute to dysfunction of bone marrow cells, the effect of hypoxic pretreatment on these functionally impaired cells is unknown. This study shows that hypoxic preconditioning enhances the angiogenic potency of the bone marrow cells with aged-related functional impairment.
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[Journal Article] Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells2012
Author(s)
Kubo M, Li TS, Kurazumi H, Takemoto Y, Ohshima M, Yamamoto Y, Nishimoto A, Mikamo A, Fujimoto M, Nakai A, Hamano K
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Journal Title
PLoS One
Volume: 7(5)
Pages: e37934
Peer Reviewed
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