2012 Fiscal Year Final Research Report
Analysis of hepatic stem cell specific histone modifications as a basis for identification of molecular targets to block hepatic carcinogenesis
| Project/Area Number |
23791491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
NAKATA Susumu 愛知県がんセンター(研究所), 腫瘍病理学部, 主任研究員 (80590695)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒストン修飾 / 肝幹細胞 / 肝細胞分化 / 肝細胞癌 |
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| Research Abstract |
We found some histone modifications that change its localization and amount between embryonic hepatic stem cells and adult hepatocytes. We identified their target genes at genomic level, demonstrating vast majority of the targets of a repressive histone mark, H3K27me3, are mutually exclusive. An integrated analysis revealed that some functional genes involved in metabolisms were repressed by H3K27me3 and that some early development-related and cell cycle-promoting genes were associated with distinct transcription activating pattern of the histone marks in the hepatic stem cells.
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[Journal Article] LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells.2013
Author(s)
Nakata S, Campos B, Bageritz J, Lorenzo Bermejo J, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V.
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Journal Title
Brain Pathology
Volume: 23(1)
Pages: 60-72
DOI
Peer Reviewed
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[Journal Article] RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.2012
Author(s)
Goidts V, Bageritz J, Puccio L, Nakata S, Zapatka M, Barbus S, Toedt G, Campos B, Korshunov A, Momma S, Van Schaftingen E, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B.
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Journal Title
Oncogene
Volume: 31(27)
Pages: 3235-43
DOI
Peer Reviewed
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[Journal Article] A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors.2011
Author(s)
Ernst A, Aigner M, Nakata S, Engel F, Schlotter M, Kloor M, Brand K, Schmitt S, Steinert G, Rahbari N, Koch M, Radlwimmer B, Weitz J, Lichter P
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Journal Title
Pathology
Volume: 43(3)
Pages: 220-7
DOI
Peer Reviewed
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[Presentation] Quantitative targeted proteomics of transporters in pancreatic cancer treated with neoadjuvant chemoradiation therapy2012
Author(s)
上野康晴, 孫略, 大内梨江, 中田晋, 鄭允文, 寺崎哲也, 倉田昌直, 山本直人, 森永聡一郎, 宮城洋平, 横瀬智之, 遠藤格, 谷口英樹
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌市教育文化会館, 札幌
Year and Date
2012-09-19
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