2012 Fiscal Year Final Research Report
Analysis of cancer stem cell properties andepithelial-mesenchymal transition signals in recurrence and metastasis of breast cancer cells
| Project/Area Number |
23791496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
ARIMA Yoshimi 慶應義塾大学, 医学部, 助教 (20309751)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌 |
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| Research Abstract |
We determined that Rb inactivation induces epithelial-mesenchymal transition, EMT through the ZEB expression. We conducted ZEB1 inhibitor screening and identified several chemical inhibitors of the ZEB1protein expression, which included CDK inhibitors. Th
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[Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer.2012
Author(s)
Arima Y,Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H
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Journal Title
J Biol Chem
Volume: 287
Pages: 7896-906
Peer Reviewed
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