2012 Fiscal Year Final Research Report
Homeobox B9 induces EMT-associated radioresistance by accelerating DNA damage responses
| Project/Area Number |
23791499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 乳癌 / HOXB9 / TGFβ / 放射線 / ATM |
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| Research Abstract |
We show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In non-irradiated cells, HOXB9 induces spontaneous DNA damage, phosphorylated histone 2AX and p53 binding protein 1 foci, and increases baseline ataxia telangiec
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[Journal Article] Homeobox B9 induces epithelial- to -mesenchymal transition -associated radioresistance by accelerating DNA damage responses.2012
Author(s)
Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S
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Journal Title
Proc Natl Acad Sci USA
Volume: 109(8)
Pages: 2760-5
DOI
Peer Reviewed
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[Journal Article] Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling2012
Author(s)
Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, Kawachi S, Tanabe M, Shinoda M, Jinno H, Hasegawa H, Kitajima M, Kitagawa Y
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Journal Title
Cancer Sci
Volume: 103(2)
Pages: 317-24
DOI
Peer Reviewed
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