2014 Fiscal Year Final Research Report
The mechanism of brown adipocyte by the surgical insult and the attenuation of hypermetabolism
| Project/Area Number |
23791500
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
YO Kikuo 慶應義塾大学, 医学部, 共同研究員 (00327644)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | Surgical metabolism / Hypermetabolism / 褐色脂肪組織 |
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| Outline of Final Research Achievements |
We used the interscapular brown adipose tissue (iBAT) for analyses. We showed burn injury increased the ratio of brown adipocyte to brown adipose tissue in the morphological analysis. In each brown adipocyte, the number of mitochondria per cell was increased. This suggests the presence of the adipose-derived stromal cells.
In the microarray analysis, we showed the increased expression of TNF and NFκB in iBAT. Lipid metabolism in iBAT was activated by burn injury. PGC1α was speculated to be involved in the differentiation of brown adipose tissue, and would be a target molecule in the development of the pharmaceutical agents for the attenuation of surgical hypermetabolism.
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| Free Research Field |
外科侵襲学
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