2015 Fiscal Year Final Research Report
The roles of novel MHC receptors, MMRs, in molecular mechanism of allograft rejection
| Project/Area Number |
23791505
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kansai University of Welfare Sciences (2014-2015)
Osaka Medical College (2011-2013) |
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Principal Investigator |
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| Research Collaborator |
Yamana Hidenori 大阪医科大学, 消化器外科学, 大学院生
Maeda Shogo 大阪医科大学, 形成外科学, 大学院生
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Keywords | 移植免疫 / 同種異系移植 / 自然免疫 |
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| Outline of Final Research Achievements |
Recently, we have isolated two novel receptors for allogeneic MHCs on macrophages/monocytes, Macrophage MHC receptor1 (MMR1) and MMR 2. In this study, we examined the physiological roles of MMR1 and MMR2. Study using generation of MMR2 knockout (KO) mice on a C57BL/6 background or binding assay with MHC molecules demonstrated that MMR1 and 2 were bound to 1 to 3 allogeneic MHC class I molecules and that MMR1 and 2 on monocytes/macrophages in mice were essential for recognition and rejection of allografted skin.
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| Free Research Field |
免疫学、分子生物学、生理
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