2013 Fiscal Year Final Research Report
cancer molecule targetting therapy with quad functional next-generationartificial bispecific antibody
| Project/Area Number |
23791512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 二重特異性抗体 / 胆道癌 / 上皮増殖因子受容体 |
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| Research Abstract |
Epidermal growth factor receptor (EGFR) is known as a key target molecule for cancer therapy because ligand binding to EGFR and its signal pathway leads to cancer cell proliferation, invasion, metastasis, angiogenesis, avoidance of apoptosis. So, blocking antibody for EGFR is now become an important therapeutic agent for cancer treatment.
We developed artificial bispecific antibody that binds both EGFR and CD3 which is a surface marker of human lymphocyte. This antibody can not only block the EGFR signal but also lead lymphocytes to cancer cells. We found that this artificial antibody had a very strong anticancer activity for EGFR positive cancer cells.
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[Journal Article] Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion : the case of the hEx3 diabody2013
Author(s)
Asano R, Kumagai T, Nagai K, Taki S, Shimomura I, Arai K, Ogata H, Okada M, Hayasaka F, Sanada H, Nakanishi T, Karvonen T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I.
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Journal Title
Protein Eng Des Sel
Volume: 26(5)
Pages: 359-67
DOI
Peer Reviewed
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[Journal Article] Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system2012
Author(s)
Asano R, Nakayama M, Kawaguchi H, Kubota T, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I.
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Journal Title
FEBS J
Volume: 279(2)
Pages: 223-33
DOI
Peer Reviewed
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[Journal Article] In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody2011
Author(s)
Watanabe Y, Asano R, Arai K, Shimomura I, Ogata H, Kawaguchi H, Hayashi H, Ohtsuka H, Yoshida H, Katayose Y, Egawa S, Nakanishi T, Umetsu M, Yasui H, Ishida T, Imai K, Kudo T, Unno M, Kumagai I.
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Journal Title
Oncol Rep
Volume: 26(4)
Pages: 949-55
DOI
Peer Reviewed
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[Presentation] 高度局所進行胆嚢癌の治療戦略と術式選択2012
Author(s)
林洋毅,力山敏樹,元井冬彦,吉田寛,森川孝則,岡田恭穂,中川圭,大塚英郎,乙供茂,水間正道,坂田直昭,深瀬耕二,石田晶玄,片寄友,江川新一,海野倫明
Organizer
第24回日本肝胆膵外科学会学術集会
Place of Presentation
大阪
Year and Date
2012-06-01
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[Presentation] Stage3以上の進行胆道癌における予後規定因子の検討ならびに手術適応の検討2012
Author(s)
林洋毅,力山敏樹,元井冬彦,吉田寛,小野川徹,森川孝則,岡田恭穂,中川圭,大塚英郎,坂田直昭,乙供茂,水間正道,深瀬耕二,石田晶玄,片寄友,江川新一,海野倫明
Organizer
第112回日本外科学会定期学術集会
Place of Presentation
千葉
Year and Date
2012-04-12
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[Presentation] The Risk Evaluation about Major Hepato-Pancreaticoduocenectomy for Cholangiocarcinoma; 24 cases2011
Author(s)
Hayashi H, Rikiyama T, Motoi F, Onogawa T, Morikawa T, Okada T, Nakagawa K, Ohtsuka H, Ottomo S, Mizuma M, Sakata N, Fukase K, Katayose Y, Egawa S, Unno M.
Organizer
21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (lASG02011 in Tokyo)
Place of Presentation
東京
Year and Date
2011-11-10
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