MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: OKUGAWA Yoshinaga 三重大学, 三重大学, 助教 (30555545)
• Project Period (FY): 2011 – 2012
• Keywords: 胃十二指腸外科学

Research Abstract

Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.

Research Products

• [Journal Article] Brain-derived neurotrophic factor /tropomyosin -related kinase B pathway in gastric cancer. (2013)
  • Author(s): Okugawa Y, Tanaka K, Inoue Y, Kawamura M, Kawamoto A, Hiro J, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y, Kusunoki M.
  • Journal Title: Br J Cancer Volume: 108(1) Pages: 121-30
  • Peer Reviewed
• [Journal Article] Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer. (2012)
  • Author(s): Okugawa Y, Inoue Y, Tanaka K, Kawamura M, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y, Kusunoki M.
  • Journal Title: Clin Exp Metastasis Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Clinical significance of serum soluble E-cadherin in colorectal carcinoma. (2012)
  • Author(s): Okugawa Y, Toiyama Y, Inoue Y, Iwata T, Fujikawa H, Saigusa S, Konishi N, Tanaka K, Uchida K, Kusunoki M.
  • Journal Title: J Surg Res Volume: 175(2) Pages: e67-73
  • Peer Reviewed
• [Journal Article] Clinical significance of Zinc finger E-box Binding homeobox 1 (ZEB1) in human gastric cancer (2012)
  • Author(s): Okugawa Y, Toiyama Y, Tanaka K, Matsusita K, Fujikawa H, Saigusa S, Ohi M, Inoue Y, Mohri Y, Uchida K, Kusunoki M.
  • Journal Title: J Surg Oncol Volume: 106(3) Pages: 280-5
  • Peer Reviewed
• [Journal Article] CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer (2012)
  • Author(s): Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M
  • Journal Title: Eur J Cancer Volume: 48(14) Pages: 2244-51
  • Peer Reviewed
• [Journal Article] Intravital dual-colored visualization of colorectal liver metastasis in living mice using two photon laser scanning microscopy. (2012)
  • Author(s): Tanaka K, Morimoto Y, Toiyama Y, Okugawa Y, Inoue Y, Uchida K, Kimura K, Mizoguchi A, Kusunoki M.
  • Journal Title: Microsc Res Tech Volume: 75(3) Pages: 307-15
  • Peer Reviewed
• [Presentation] Brain derived neurotrophic factor/Tropomyosin-related kinase B (TrkB) axis caused peritoneal dissemination via anoikis resistant in gastric cancer. (2012)
  • Author(s): 奥川喜永 ほか
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] 胃癌組織における miR151-5p 発現の臨床病理学的意義 (2012)
  • Author(s): 奥川喜永 ほか
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
  • Year and Date: 2012-07-20