2013 Fiscal Year Final Research Report
Models of liver regeneration using the fibrotic mice.
| Project/Area Number |
23791531
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
KURAMITSU Kaori 神戸大学, 医学部附属病院, 特定助教 (80596784)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肝再生 |
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| Research Abstract |
In our experiment, we could establish the experimental model of fibrosis mouse by introducing CCl4 orally to mice. By changing the introduction time, we could make F1 to F4 mice.
In basic science, the experimental model was utilized to suppress the fibrosis stage, and there was no experiments focused on liver regeneration. However, in clinical situations, we need to focus on the fibrosis stage to perform hepatectomy, as background liver status is usually injured for virus infection. In our experiments, we could analyze liver regeneration based on the different fibrosis stage. Our experiment achieved the novel strategy for hepatectomy based on the background fibrosis stage.
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