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2012 Fiscal Year Final Research Report

The role of sonic hedgehog signaling in intestinal injury

Research Project

  • PDF
Project/Area Number 23791536
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHIKAWA Kozo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80448331)

Co-Investigator(Renkei-kenkyūsha) SHIMADA Mitsuo  徳島大学, 大学院・ヘルスバイオサイ エンス研究部, 教授 (10216070)
KURITA Nobuhiro  徳島大学, 病院, 特任教授 (30335814)
IWATA Takashi  徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 准教授 (00380022)
Project Period (FY) 2011 – 2012
Keywordsソニックヘッジホッグシグナル / 腸管修復 / サイトカイン
Research Abstract

In intestinal stress rat model, the component of the Sonic hedgehog pathway was up-regulated and tight junction (Occludin, Claudin, ZO-1) was down-regulated. In cancer stem cell (CSC), Sonic hedgehog pathway was correlated with CSC.

  • Research Products

    (9 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] The effects of the Kampo medicine "Daikenchuto"on the surgical inflammatory response following laparoscopic colorectal resection.2012

    • Author(s)
      Yoshikawa K et al
    • Journal Title

      Surg Today

      Volume: 42 Pages: 646-651

    • Peer Reviewed
  • [Journal Article] The efficacy of PET-CT for predicting the malignant potential of gastrointestinal stromal tumors.2012

    • Author(s)
      Yoshikawa K et al
    • Journal Title

      Surg Today

    • Peer Reviewed
  • [Journal Article] Personalized medicine for laparoscopic gastrectomy used to treat gastric cancer2012

    • Author(s)
      Yoshikawa K et al
    • Journal Title

      Surg Endosc

      Volume: 26 Pages: 3073

    • Peer Reviewed
  • [Journal Article] Visceral fat area is superior to body mass index as a predictive factor for risk with laparoscopy-assisted gastrectomy for gastric cancer.2011

    • Author(s)
      Yoshikawa K et al
    • Journal Title

      Surg Endosc

      Volume: 25 Pages: 3825-3830

    • Peer Reviewed
  • [Presentation] 腸管ストレスにおける大建中湯の抗炎症効果2012

    • Author(s)
      吉川幸造
    • Organizer
      第67回消化器外科学会
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2012-07-20
  • [Presentation] CPT-11 投与による腸間ストレスに対する大健中湯の効果に関する検討2012

    • Author(s)
      吉川幸造
    • Organizer
      第49回外科代謝栄養
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県)
    • Year and Date
      2012-07-05
  • [Presentation] The effect of Dai-kenchu-to in maintenance of microbiomal diversity on intestinal inflammation.2012

    • Author(s)
      吉川幸造
    • Organizer
      第98回消化器病学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-04-19
  • [Presentation] CPT-11 は Tight Junction 障害と TNFα ・NF-kB経路を介しBacterial Translocation を発症させる2012

    • Author(s)
      吉川幸造
    • Organizer
      第112回外科学会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2012-04-12
  • [Presentation] 大建中湯の新たな抗炎症効果機序の解明 腸管マイクロバイオームのDiversity 維持に注目して2011

    • Author(s)
      吉川幸造
    • Organizer
      第111回外科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-05-26

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Published: 2014-09-25  

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