2012 Fiscal Year Final Research Report
The elucidation of the novel microRNA-gene pathway regulating the peritoneal dissemination in gastric cancer
| Project/Area Number |
23791550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Research Collaborator |
BABA Hideo 熊本大学, 生命科学研究部, 教授 (20240905)
WATANABE Masayuki 熊本大学, 生命科学研究部, 准教授 (80254639)
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| Project Period (FY) |
2011 – 2012
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| Keywords | microRNA / 胃癌 / 腹膜播種 / 転移 / 化学療法耐性 / exosome |
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| Research Abstract |
The prognosis of the patients with peritoneal dissemination of gastric cancer still remains dismal. The molecular mechanism of peritoneal dissemination has been not elucidated. microRNA has been reported to be involved in carcinogenesis, progress, metastasis and chemo-resistance. In the current study, we aimed to reveal the novel microRNA- gene pathway in human serum samples regulating the malignant potential of gastrointestinal cancer.
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[Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013
Author(s)
Yokobori T, Iinuma H, Shimamura T,Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T,Nishida N, Kogo R, Sudo T, Tanaka F,Shibata K, Toh H, Sato T, Barnard GF,Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M
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Journal Title
CancerRes
Volume: 73
Pages: 2059-69
DOI
Peer Reviewed
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[Journal Article] MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M,Hiyoshi Y, Iwatsuki M, Tanaka Y,Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Ann Surg Oncol
Volume: 19
Pages: S656-64
DOI
Peer Reviewed
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