2013 Fiscal Year Final Research Report
Measurement of pulmonary arterial flow velocity and shear stress using synchrotron radiation pulmonary micro-angiography in pulmonary hypertension
| Project/Area Number |
23791560
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 放射光微小血管撮影 / 肺高血圧症 / シアストレス / 血管内皮細胞障害 |
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| Research Abstract |
Congenital heart disease with high pulmonary blood flow is frequently complicated by the development of irreversible pulmonary hypertension. Increased shear stress may play a key role to induce intimal and medial hypertrophy and increase vascular resistance. We performed the pulmonary angiography in high flow pulmonary hypertension rat model by using synchrotron radiation micro-angiography to visualize the pulmonary microvasculature and measure the pulmonary flow velocity. The velocity of pulmonary artery in the high flow pulmonary hypertension rat model was significantly increased compared with the control (82.3 plusminus 8.5 mm/sec vs. 46.1 plusminus 4.3 mm/sec, p<0.05). Synchrotron radiation micro-angiography was useful for measuring the pulmonary blood flow velocity. This newly developed technology may help to investigate the mechanism of vascular remodeling associated with high flow pulmonary hypertension.
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