2012 Fiscal Year Final Research Report
Activation of Receptor Tyrosine Kinase and the Possibility of the Target Therapy on Malignant Pleural Mesothelioma
| Project/Area Number |
23791565
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
KAWAGUCHI Koji 名古屋大学, 医学部附属病院, 病院助教 (10402611)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 悪性胸膜中皮腫 / 受容体チロシンキナーゼ / 細胞株樹立 / MET / 分子標的薬 |
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| Research Abstract |
Malignant pleural mesothelioma (MPM) is a devastating disease with resistance to conventional therapies. We analyzed the effect of combined inhibition of MET and EGFR on malignant mesothelioma cell lines in vitro. And to test the effect of this combination in vivo, we established orthotopic xenograft models of human MPM cells and performed a preliminary experiment to administer inhibitors of MET and EGFR. We showed that combined inhibition of MET and EGFR exerted a stronger inhibitory effe ct on MPM cell proliferation in vivo.
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[Journal Article] Japanese Joint Committee of Lung Cancer Registry.Modern surgical results of lung cancer involving neighboring structures: A retrospective analysis of 531 pT3 cases in a Japanese Lung Cancer Registry Study.2012
Author(s)
Kawaguchi K, Miyaoka E, Asamura H, Nomori H, Okumura M, Fujii Y, Nakanishi Y, Eguchi K, Mori M, Sawabata N, Yokoi K;
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Journal Title
J Thorac Cardiovasc Surg.
Volume: 144(2)
Pages: 431-7
Peer Reviewed
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