2012 Fiscal Year Final Research Report
Investigation of cellular function of cardiac fibroblasts in cardiac regeneration
| Project/Area Number |
23791568
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 重症心不全 / 心筋線維化 / 補助人工心臓 / 細胞治療 |
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| Research Abstract |
This study was to explore mechanisms related to improvement in cardiac function of advanced heart failure with a specific focus on fibrosis in the cardiac tissue. Firstly, cardiac tissue was surgically sampled from the patients having advanced heart failure at the time of left ventricular device implantation and at the time of cardiac transplantation. As a result, mechanical support by the device improved cardiac function but not reduced cardiac fibrosis. In contrast, regenerative treatment for a rat advanced heart failure model induced dynamic up-regulation and down-regulation of the factors related to synthesis and degradation of the fibrosis, consequently reducing cardiac fibrosis, indicating the importance of cardiac fibrosis in advanced heart failure.
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[Journal Article] Improvement of Cardiac Stem Cell-Sheet Therapy for Chronic Ischemic Injury by Adding Endothelial Progenitor Cell Transplantation: Analysis of Layer-Specific Regional Cardiac Function2013
Author(s)
Kamata S, Miyagawa S, Fukushima S, Nakatani S, Kawamoto A, Saito A, Harada A, Shimizu T, Daimon T, Okano T, Asahara T, Sawa Y
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Journal Title
URL
Peer Reviewed
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[Journal Article] Myocardial layer-specific effect of myoblast cell-sheet implantation evaluated by tissue strain imaging2012
Author(s)
Shudo Y, Miyagawa S, Nakatani S, Fukushima S,Sakaguchi T, Saito A, Asanuma T, Kawaguchi N, Matsuura N, Shimizu T, Okano T, Sawa Y
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Journal Title
Circ J
Volume: 12
Pages: 0615
Peer Reviewed
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[Journal Article] Myoblast sheet can prevent the impairment of cardiac diastolic function and late remodeling after left ventricular restoration in ischemic cardiomyopathy2012
Author(s)
Saito S, Miyagawa S, Sakaguchi T, Imanishi Y, Iseoka H, Nishi H, Yoshikawa Y, Fukushima S, Saito A, Shimizu T, Okano T, Sawa Y
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Journal Title
Transplantation
Volume: 93
Pages: 1108-15
DOI
Peer Reviewed
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[Journal Article] Induced adipocyte cell-sheet ameliorates cardiac dysfunction in mouse myocardial infarction model - A novel drug delivery system for heart failure2011
Author(s)
Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, Hirata A, Shimizu T, Okano T, Shimomura I, Sawa Y
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Journal Title
Circulation
Volume: 124
Pages: S10-7
DOI
Peer Reviewed
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