Analysis of immune response to overcome immune-escape of lung cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791580
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: SHIGEMATSU Yoshiki 産業医科大学, 医学部, 助教 (10546469)
• Project Period (FY): 2011 – 2012
• Keywords: 肺癌 / 腫瘍免疫 / 免疫逃避機構 / 制御性T細胞 / HLA

Research Abstract

The purpose of this study was to evaluate immune response in patients with non-small cell lung cancer (NSCLC) to overcome the tumor immune escape mechanism. The higher proportion of CD4+ CD25+ Foxp3+ regulatory T cells in the regional lymph node was a significant unfavorable prognostic factor, even in patients with node-negative NSCLC. The normal expression of HLA-class I was associated with a favorable prognosis in comparison with the heterogeneous expression group. It is necessary to evaluate the efficacy of adjuvant immunotherapy in consideration of clinical significance of the HLA expression pattern and the proportion of regulatory T cells.

Research Products

• [Journal Article] Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma (2013)
  • Author(s): Baba T, Shiota H, Kuroda K, Shigematsu Y, Ichiki Y, Uramoto H, Hanagiri T, Tanaka F
  • Journal Title: Eur J Cardiothorac Surg Volume: 43(4) Pages: 759-64
  • Peer Reviewed
• [Journal Article] Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients (2012)
  • Author(s): aba T, Shiota H, Kuroda K, Shigematsu Y, Ichiki Y, Uramoto H, Hanagiri T, Tanaka F
  • Journal Title: Int J Clin Oncol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes (2012)
  • Author(s): Shigematsu Y, Hanagiri T, Shiota H, Kuroda K, Baba T, Ichiki Y, Yasuda M, Uramoto H, Takenoyama M, Yasumoto K, Tanaka F
  • Journal Title: Oncol Lett Volume: 4(4) Pages: 625-630
  • Peer Reviewed
• [Journal Article] Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer (2012)
  • Author(s): Hanagiri T, Shigematsu Y, Kuroda K, Baba T, Shiota H, Ichiki Y, Nagata Y, Yasuda M, Uramoto H, So T, Takenoyama M, Tanaka F
  • Journal Title: J Surg Res Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 肺癌所属リンパ節における制御性T細胞および微小リンパ節転移の解析 (2012)
  • Author(s): 花桐 武志, 重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 下川 秀彦, 中川 誠, 永田 好香, 浦本 秀隆, 宗 知子, 田中 文啓
  • Organizer: 第50回日本癌治療学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20121025-1027
• [Presentation] 肺癌所属リンパ節における制御性T細胞の臨床病理学的意義 (2012)
  • Author(s): 花桐 武志, 重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 下川 秀彦, 中川 誠, 永田 好香, 岩田 輝男, 浦本 秀隆, 宗 知子, 田中 文啓
  • Organizer: 第53回日本肺癌学会
  • Place of Presentation: 岡山コンベンションセンター、ホテルグランヴィア岡山、岡山市デジタルミュージアム、岡山全日空ホテル
  • Year and Date: 20121025-1027
• [Presentation] 非小細胞肺癌における腫瘍抗原およびHLA class Iの発現;癌特異的免疫療法への基盤的研究 (2012)
  • Author(s): 花桐武志,黒田耕志、重松義紀,永田好香,馬場哲郎,浦本秀隆,宗 知子,竹之山光広,田中文啓
  • Organizer: 第29回日本呼吸器外科学会
  • Place of Presentation: 秋田県民会館、秋田キャッスルホテル
  • Year and Date: 20120517-0518
• [Presentation] 非小細胞肺癌における癌精巣抗原発現とワクチン療法への応用 (2012)
  • Author(s): 重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 馬場 哲郎, 下川 秀彦, 中川 誠, 浦本 秀隆, 宗 知子, 花桐 武志, 田中 文啓
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 幕張メッセ、ホテルニューオータニ幕張
  • Year and Date: 20120412-0414
• [Presentation] 肺癌患者における制御性T細胞の発現と役割 (2011)
  • Author(s): 重松義紀, 黒田耕志, 馬場哲郎, 竹中賢, 近石泰弘, 岡壮一, 中川誠, 下川秀彦, 浦本秀隆, 宗知子, 花桐武志, 田中文啓
  • Organizer: 第39回日本臨床免疫学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 20110915-0917