2012 Fiscal Year Final Research Report
Development of immuno-gene therapy strategy using co-stimulatorymolecule linking local treatment and systemic anti-tumor effect.
| Project/Area Number |
23791583
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Ryuta 東北大学, 大学院・医学系研究科, 助教 (10400243)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 中枢神経系薬剤送達 / 腫瘍ワクチン / 脳腫瘍 / 化学療法 / 免疫治療 / 共刺激因子 |
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| Research Abstract |
In this study, we confirmed that co-stimulatory molecule OX-40 plays pivotal role in inducing strong anti-tumor efficacy. Using OX-40 agonistic antibody, immunostimulatory effect was evaluated. Induction of anti-tumor effect was strongest when OX-40 signal was activated together with subcutaneous tumor vaccination. Thus, we tried to develop new immunotherapeutic strategy against glioblastoma. Activation of OX-40 signaling can be promising immunotherapy for glioblastoma.
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