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2013 Fiscal Year Final Research Report

Development of the in vivo imaging technology in WT1 peptide vaccination for malignant brain tumor.

Research Project

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Project/Area Number 23791597
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

CHIBA Yasuyoshi  大阪大学, 医学(系)研究科(研究院), 助教 (90533795)

Project Period (FY) 2011 – 2012
Keywords悪性グリオーマ / WT1 / 免疫療法 / 癌ワクチン / 腫瘍浸潤リンパ球 / in vivoイメージング / メチオニンPET / GFPマウス
Research Abstract

We developed the suitable imaging evaluation method for WT1 peptide vaccination for recurrent malignant gliomas. Usually, it is although the treatment evaluation for a brain tumor is performed by MRI in many cases, it became clear that the evaluation by MRI does not reflect survival time and that the accumulation value and volume evaluation using the methionine-PET reflected survival time comparatively by this research. The appraisal method which reflected survival time most was an method using parametric response map (PRM) which united the methionine PET before and after WT1 peptide vaccination, and expressed change of the accumulation value to each voxel (1 mm3).

  • Research Products

    (15 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (13 results)

  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012

    • Author(s)
      Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T.
    • Journal Title

      J Neurosurg

      Volume: 116(4) Pages: 835-842

    • DOI

      10.3171/2011.12.JNS11125

    • Peer Reviewed
  • [Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan2011

    • Author(s)
      Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T.
    • Journal Title

      Int J Clin Oncol

      Volume: 16 (3) Pages: 230-237

    • DOI

      10.1007/s10147-010-0152-8

    • Peer Reviewed
  • [Presentation] WT1ペプチドワクチン療法におけるMRIを用いた画像評価法の検討2013

    • Author(s)
      千葉泰良
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      宮崎
    • Year and Date
      2013-12-09
  • [Presentation] Immune escape in human malignant gliomas after WT1 peptide vaccination2013

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      SNO 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      San Francisco , USA
    • Year and Date
      2013-11-23
  • [Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の免疫逃避機構2013

    • Author(s)
      千葉泰良
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-18
  • [Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の腫瘍浸潤リンパ球と免疫逃避2013

    • Author(s)
      千葉泰良
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with recurrent maligtant glioma after WT1 Peptide Vaccination2013

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 10th Annual Meeting of the Asian Society for Neuro-oncology (ASNO)
    • Place of Presentation
      Mumbai, India
    • Year and Date
      2013-03-23
  • [Presentation] グリオーマにおける1p19q共欠失とα-internexin発現との関連2012

    • Author(s)
      千葉泰良
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-26
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with maligtant glioma receiving WT1 Peptide Vaccination2012

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 6th International Conference on WT1 in Human Neoplasia
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-11-23
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with maligtant glioma receiving WT1 Peptide Vaccination2012

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      SNO 17th Annual Scientific Meeting
    • Place of Presentation
      Washington DC , USA
    • Year and Date
      2012-11-17
  • [Presentation] WT1ワクチン療法における画像と免疫学的指標を用いた治療効果評価2012

    • Author(s)
      千葉泰良
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-18
  • [Presentation] 11 C-methionine PETを用いたparametric response mapによるWT1療法の効果判定2011

    • Author(s)
      千葉泰良
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-27
  • [Presentation] Voxel-wise functional 11C-methionine positron emission tomography analysis but not conventional MRI corresponds to treatment response of WT1 immunotherapy for recurrent high-grade glioma2011

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      16th Annual Scientific Meeting of Society for NeuroOncology
    • Place of Presentation
      California, USA
    • Year and Date
      2011-11-18
  • [Presentation] 悪性グリオーマに対するWT1ペプチドワクチン療法後の浸潤リンパ球と免疫逃避2011

    • Author(s)
      千葉泰良
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
  • [Presentation] 再発GBMに対するWT1ペプチド療法におけるHLA class発現と予後との関連2011

    • Author(s)
      千葉泰良
    • Organizer
      第69回日本脳腫瘍病理学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21

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Published: 2015-06-25  

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