2013 Fiscal Year Final Research Report
The effects of deep brain stimulation on sensory function in Parkinson's disease.
| Project/Area Number |
23791598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
MARUO Tomoyuki 大阪大学, 医学(系)研究科(研究院), 特任助教 (90533810)
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| Project Period (FY) |
2011 – 2012
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| Keywords | パ－キンソン病 / 視床下核刺激 / 脳血流 |
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| Research Abstract |
Parkinson's disease is the most common of the neurodegenerative disease which has the motor symptoms. In addition to motor symptoms, sensory disturbances are part of the clinical picture of Parkinson's disease. Little is known about the effects of deep brain stimulation (DBS) on sensory symptoms and the mechanisms by which DBS alleviates sensory symptoms in Parkinson's disease. The aim of our study was to evaluate the effects of DBS on cerebral blood flow (CBF). We used Parkinson's model rats created by the nigra injection of 6-hydroxydopamine (6-OHDA) that enabled us to investigate CBF using laser speckle flowmetry (LSF), thus allowing the continuous imaging of the spatiotemporal dynamics of CBF changes in rats. We observed that CBF in primary sensorimotor area had increased temporarily during STN-DBS. LSF is useful to assess the changes in CBF that are related to neural activity, and the mechanisms of deep brain stimulation, with high temporal and spatial resolution.
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