2013 Fiscal Year Final Research Report
The inhibition effects of the Kynurenine pathway on brain tumor stem cells and its niche.
Project/Area Number |
23791601
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cerebral neurosurgery
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Research Institution | Shimane University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
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Keywords | glioblastoma / brain tumor stem cells / Kynurenine pathway |
Research Abstract |
Immunohistological examination revealed that Indoleamine 2,3 dioxygenase(IDO) positive cells in glioblastoma(GBM) tissue overlap the cells which construct the characteristic structure indicating GBM. The sphere cells (brain tumor stem cells: BTSC) enriched by the sphere culture method from the GBM patient showed high IDO reactivity on not only level of gene expression but also the enzyme activity compared with diffenretiated cells from sphere cells by serum stimulation. These data support IDO targeted strategy for BTSC in GBM treatment will be highly effective coupled with the fact that IDO inhibition may restore host's immune response against GBM.
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Research Products
(2 results)