2012 Fiscal Year Final Research Report
Elucidation of the role of the ectopic aquaporin 1 in the onset of hydrocephalus of the kaolin-induced hydrocephalus model in rat
| Project/Area Number |
23791613
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJITA Masataka 名古屋市立大学, 大学院・医学研究科, 研究員 (10360637)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 実験脳外科学 |
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| Research Abstract |
We examined how ectopic AQP1, which increased at the development of hydrocephalus, influenced the hydrocephalus formation using the kaolin-induced hydrocephalus model in rat by RNAi knockdown. As the preparation, production of rabbit anti-AQP1 serum suitable for a Western blot was successful and the arrangement of siRNA suitable for knockdown was found out. However, the suitable method of the injection for in vivo RNAi could not establish within this period, so it remains as a future subject.
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