2013 Fiscal Year Final Research Report
Beta oscillatory activity of single neurons in the subthalamic nucleus in patients with Parkinson's disease
| Project/Area Number |
23791616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | パーキンソン病 / 脳深部刺激療法 / 微小電極記録 / STN / オシレーション |
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| Research Abstract |
We analyzed the frequencies of single neurons of subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD). The neurons were classified as beta-band neurons and nonoscillatory neurons. Firing rates, distributions within the STN, and the proportions of kinesthetic neurons were compared between the 2 groups.
The firing rate of beta-band neurons was significantly higher than that of nonoscillatory neurons. Beta-band neurons were widely distributed within the STN, and there was no significant intergroup difference in neuron distribution between the dorsal STN and the ventral STN. We did not note any significant intergroup difference in the proportion of kinesthetic neurons.
The higher firing rate of beta-band neurons was consistent with the firing rate model of akinesia. The dorsal STN is a motor area, but the beta-band activity of a single neuron may not specifically reflect the motor symptoms of PD because of the wide distribution of beta-band neurons.
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[Journal Article] Simulation to locate burr hole sites in a patient for deep brain stimulation surgery and clipping of intracranial aneurysm2013
Author(s)
Kobayashi K, Nakamura S, Watanabe M, Shimoda K, Morishita T, Sumi K, Otaka T, Obuchi T, Shijyo K, Kano T, Oshima H, Fukaya C, Yamamoto T, Katayama Y.
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Journal Title
Neuromodulation
Volume: 16
Pages: 51-54
Peer Reviewed
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[Presentation] Beta oscillatory activity of single neurons in the subthalamic nucleus in patients with Parkinson's disease2013
Author(s)
Kobayashi K, Watanabe M, Sumi K, Obuchi T, Kano T, Oshima H, Fukaya C, Yoshino A, Yamamoto T, Katayama Y.
Organizer
16th Meeting of World Society for Stereotactic and Functional Neurosurgery (Tokyo, Japan)
Place of Presentation
Tokyo, Japan
Year and Date
2013-05-30
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