2012 Fiscal Year Final Research Report
Functional analysis of Btbd7 in limb formation and chondrogenesis
| Project/Area Number |
23791622
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 軟骨再生 / 軟骨修復 / 再生医療 |
|---|
| Research Abstract |
We hypothesized that Gene expression of Btbd7 has an important role in limb formation and chondrogenesis. Chondrogenic differentiation model of mouse chondrocyte progenitor cell revealed that Btbd7, Snail2, and chemokine SDF-1 showed same expression pattern. These genes were transiently upregulated in chondrogenesis process. Therefore, we have driven forward our study focusing on SDF-1. We revealed that SDF-1 was transiently expressed in healing process of cartilage in vivo. In addition, we clarified that chondrogenesis was promoted by using alginate gel with SDF-1.
|
Research Products
(3 results)
