2012 Fiscal Year Final Research Report
Functional analysis of Btbd7 in limb formation and chondrogenesis
| Project/Area Number |
23791622
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 軟骨再生 / 軟骨修復 / 再生医療 |
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| Research Abstract |
We hypothesized that Gene expression of Btbd7 has an important role in limb formation and chondrogenesis. Chondrogenic differentiation model of mouse chondrocyte progenitor cell revealed that Btbd7, Snail2, and chemokine SDF-1 showed same expression pattern. These genes were transiently upregulated in chondrogenesis process. Therefore, we have driven forward our study focusing on SDF-1. We revealed that SDF-1 was transiently expressed in healing process of cartilage in vivo. In addition, we clarified that chondrogenesis was promoted by using alginate gel with SDF-1.
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