Comprehensive understanding of the central nerve compensation mechanism in the human myelopathy

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791625
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Gunma University
• Principal Investigator: HITOSHI Shitara 群馬大学, 医学部附属病院, 助教 (20588652)
• Project Period (FY): 2011 – 2012
• Keywords: fMRI / 経頭蓋磁気刺激 / 末梢神経電気刺激 / 筋電図 / 脊髄 / 体性感覚入力

Research Abstract

We delivered suprathreshold TMS to left M1 or gave electrical right median nerve stimulation in healthy volunteers while simultaneously conducting fMRI and monitoring with EMG. We examined in detail the localization of TMS-, muscle afferent- and superficial afferent-induced activity in M1 subdivisions. Muscle afferent-and TMS-evoked activity occurred mainly in rostral M1, while superficial afferents generated a slightly different activation distribution. This result was almost consistent with the previous study in squirrel monkeys (Strick & Preston, 1982). The present study appears to justify the use of fMRI combined with suprathreshold TMS to M1 for evoked motor network imaging.
Next, we developed a novel MRI scanning technique which enables us to measure neuronal activity in the brain and the spinal cord simultaneously. Using this technique, to our knowledge, we first demonstrated a cerebrospinal functional coupling during motor tasks in human, noninvasively.

Research Products

• [Journal Article] Movement and afferent representations in human motor areas : a simultaneous neuroimaging and transcranial magnetic/peripheral nerve-stimulation study (2013)
  • Author(s): Shitara H, Shinozaki T, Takagishi K, Honda M, Hanakawa T
  • Journal Title: Frontiers in Human Neuroscience Volume: 17; 7 Pages: 554
  • DOI: 10.3389/fnhum.2013.00554
  • Peer Reviewed
• [Presentation] 機能的MRIによる非侵襲的な脳・頚髄神経活動の同時計測・評価法を用いた脳頚髄間の機能連関の検証-新たな中枢神経系評価法の確立に向けて- (2014)
  • Author(s): 高澤英嗣,花川隆,設楽仁,角田大介,三枝徳江,飯塚陽一,飯塚伯,高岸憲二
  • Organizer: 第43回日本脊椎脊髄病学会
  • Place of Presentation: 京都
  • Year and Date: 20140400
• [Presentation] 非侵襲的ヒト大脳頚髄同時評価システムの構築―機能的MRIを用いた研究― (2013)
  • Author(s): 高澤英嗣,花川隆,設楽仁,反町泰紀,中島飛志,西野目昌宏,荒毅,小林亮一,飯塚陽一,飯塚伯,高岸憲二
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 沖縄
  • Year and Date: 20130400
• [Presentation] Functional correlations between the primary motor cortex and spinal motor neurons during motor tasks using a developed simultaneous recording technique of the functional magnetic resonance imaging data in the two regions (2013)
  • Author(s): Takasawa E., Hanakawa T., Shitara H., Iizuka Y., Iizuka H., Takagishi K.
  • Organizer: Eurospine 2013
  • Place of Presentation: Livepool, UK
  • Year and Date: 2013-10-02
• [Presentation] fMRI,筋電図,経頭蓋磁気刺激(TMS),正中神経電気刺激の同時計測による運動野・体性感覚野のマッピング (2012)
  • Author(s): 設楽仁,篠崎哲也,高岸憲二,花川隆,本田学
  • Organizer: 第27回日本整形外科基礎学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20121000