2012 Fiscal Year Final Research Report
Analysis of tumor protein in acidic condtion and Development of magnetic hyperthermia for tumor acidic target
| Project/Area Number |
23791635
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
小林 猛 中部大学, 応用生物学部, 教授
淺沼 由美子 国立三重中央病院, 医院
林 辰弥 三重県立看護大学, 教授
岡本 貴行 三重大学, 分子病態学, 助教
松原 孝夫 三重大学, 整形外科, 助教
中村 知樹 三重大学, 整形外科, 助教
松峯 昭彦 三重大学, 整形外科, 准教授
須藤 啓広 三重大学, 整形外科, 助教
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨・軟部腫瘍学 |
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| Research Abstract |
mRNA expression and protein production of CAIX（Carbonic Anhydrase）was expressed in tumor cells in acidic condtion. CAIX is thought to be one of the target factor for nanomagnetite and drug deliverly in acidic condition around tumor tissues. Additionally, CAIX inhibitors prevented tumor growth in vivo. These leads to the possibility that antibody angainst functional site of CAIX epitope has synergy effect for nanomagnetite and drug delivery. Furthermore, inhibitory effect of cell proliferation was analized using 320 drugs of compound library. 9 drugs for osteosarcomas and 4 drugs for soft tissue sarcomas were selected. Thses slected drugs may be useful for drug delivery by CAIX targeted liposome.
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