2012 Fiscal Year Final Research Report
Establishment of the assay system of drug screening for fibrodysplasia ossificans progressiva
| Project/Area Number |
23791636
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
IKEYA Makoto 京都大学, iPS細胞研究所, 准教授 (20442923)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 進行性骨化症線維異形成症 |
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| Research Abstract |
I have generated iPSCs from patients of fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterized by progressive ossification in soft tissues. I have revealed that FOP iPSCs showed increased mineralization and enhanced chondrogenesis in vitro. I also established the assay system of drug screening to suppress the enhanced mineralization of FOP-iPSCs.
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Research Products
(11 results)
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[Journal Article] Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.2013
Author(s)
Nasu A, Ikeya M, Yamamoto T,Watanabe A, Jin Y, Matsumoto Y,Hayakawa K, Amano N, Sato S,Osafune K, Aoyama T, Nakamura T,Kato T, Toguchida J.
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Journal Title
PLoS One.
Volume: 8(1)
Pages: e53771
DOI
Peer Reviewed
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[Presentation] Modeling Inherited Skeletal Disease in Human iPS Cells.2012
Author(s)
Schlieve R, Matsumoto Y, Hayashi Y, Kim H, Nguyen T, Sami S, Yamanaka S, Ikeya M,Toguchida J, Conklin B, Hsiao E:
Organizer
第10回国際幹細胞生物学会、ポスター発表、
Place of Presentation
横浜
Year and Date
2012-06-15
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[Presentation] Matsumoto Y, Ikeya M, Nasu A, Asaka I, Otsuka T, Hsiao E, Toguchida J:of fibrodysplasia ossificance progressive.2011
Author(s)
Matsumoto Y, Ikeya M, Nasu A, Asaka I, Otsuka T, Hsiao E, Toguchida J:
Organizer
アメリカ骨代謝学会、ポスター発表
Place of Presentation
サンディエゴ、アメリカ、
Year and Date
2011-09-16
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