2012 Fiscal Year Final Research Report
Pathological analysis and drug discovery for vertebral disc egeneration using Sox90CreERT2 mice
| Project/Area Number |
23791637
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SO Kazutaka 京都大学, 医学研究科, 助教 (30514038)
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| Project Period (FY) |
2011 – 2012
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| Keywords | TGF-beta / 椎間板 / 低分子化合物 |
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| Research Abstract |
in situ hybridization and immunohistochemistry showed that TGFBR-II conditional deficient mice had growth and differentiation abnormality of growth plate chondrocytes in endoplates. This abnormality was not improved by IGF-I injection. Next, to discover new drugs for the treatment of vertebral disc degeneration, we screened about 2000 chemical reagents using TGFBR-II null primary chondrocytes, and so far we have not got a targetreagent yet.
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