The role of TROY after the spinal cord injury and application ofTROY for the treatment of injuries of the central nervous system.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HISAOKA Tomoko 和歌山県立医科大学, 医学部, 助教 (00398463)
• Project Period (FY): 2011 – 2012
• Keywords: 再生医学 / 脊髄損傷 / サイトカイン / グリア瘢痕 / 嗅神経被覆グリア

Research Abstract

First, we investigated the expression pattern of TROY in thedeveloping and adult spinal cord. TROY was expressed in the nestin-positive,GLAST-negative neural progenitor/radial glial cells in the spinal cord during embryonicstages. During postnatal stages, TROY was exclusively expressed in the GFAP- orS100-positive astrocytes in the spinal cord. Next, we investigated the expression ofTROY in the spinal cord after dorsal hemisection of the spinal cord. A few TROY-positivecells were observed around the injury site. These results suggest that TROY may beinvolved in the development of dorsal subpopulation of neural progenitor/radial glialcells and astrocytes in the spinal cord.