2012 Fiscal Year Final Research Report
Clarification of the physiological role of vasopressin in acute and chronic arthritis: using transgenic animals
| Project/Area Number |
23791671
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
ISHIKURA Toru 産業医科大学, 医学部, 助教 (70580281)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子改変動物 / c-fos遺伝子 / 蛍光タンパク / バゾプレッシン / 疼痛 |
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| Research Abstract |
We examined the expression of the c-fos-mRFP1 fusion gene in dorsal horn of the spinal cord and the paraventricular nucleus after acute nociceptive stimulation by subcutaneous (s.c.) injection of formalin or TRPV4 agonist in hind paw of the c-fos-mRFP1 transgenic rats. We observed significant increases of mRFP1 fluorescence after s.c. injection of formalin or TRPV4 agonist. These transgenic rats are useful models to study central nervous system responses to nociceptive stress.
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Research Products
(25 results)
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[Journal Article] Induction of arginine vasopressin-enhanced green fluorescent protein expression in the locus coeruleus following kainic acid-induced seizures in rats2012
Author(s)
Ohno, M. Fujihara, H. Iwanaga, M. Todoroki, M. Katoh, A. Ohbuchi, T. Ishikura, T. Hamamura, A. Hachisuka, K. & Ueta, Y
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Journal Title
Stress
Volume: 15(4)
Pages: 435-442
DOI
Peer Reviewed
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[Journal Article] Expression of the c-fos-monomeric red fluorescent protein 1 fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after formalin injection2012
Author(s)
Ishikura, T. Suzuki, H. Yoshimura, M. Ohkubo, J. Katoh, A. Ohbuchi, T. Ohno, M. Fujihara, H. Kawasaki, M. Ohnishi,H. Nakamura, T. & Ueta, Y
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Journal Title
Brain Research
Volume: 1479
Pages: 52-61
DOI
Peer Reviewed
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[Presentation] Expression of the c-fos-monomeric red fluorescent protein 1 fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after formalin injection2012
Author(s)
Ishikura, T. Suzuki, H. Matsuura, T. Yoshimura, M. Ohkubo, J. Ohno, M. Ohnishi, H. Nakamura, T. Kannan, H. Ueta, Y
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA
Year and Date
20121013-17
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