2013 Fiscal Year Final Research Report
Targeting the genomic loci of idiopathic scoliosis
| Project/Area Number |
23791676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Hospital Organization Murayama Medical Center |
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Principal Investigator |
YAGI Mitsuru 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医長 (40338091)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨・軟骨代謝学 |
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| Research Abstract |
The high prevalence and variability of familial idiopathic scoliosis is indicative of genetic heterogeneity. To localize genes related to scoliosis, groups of families with common clinical characteristics have been identified in an attempt to reduce genetic heterogeneity. Recent work has provided evidence that adolescent idiopathic scoliosis is linked to several different loci; however, the limited number of microsatellite makers used in the study made the linkage analysis less efficient.The aim of this study was to identify the genomic locus of familial idiopathic scoliosis. We identified five SNPs in four genes in three previously reported candidate genomic loci thought to be responsible for the development of idiopathic scoliosis. The candidate genes exhibited the strongest evidence for linkage in all of the analyses considered. All of the candidate genes have been identified as essential for skeletal and axonal growth.
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[Presentation] 成人脊柱変形患者における矢状面重心線とC7鉛直線の相違発生頻度とリスク因子の検討2013
Author(s)
八木満,長谷川淳,町田真理,安田明正,許斐恒彦,名越慈人,三宅敦,藤吉兼浩,金子慎二郎,竹光正和,町田正文,朝妻孝仁
Organizer
第47回日本側彎症学会
Place of Presentation
高知
Year and Date
20131023-24
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