2012 Fiscal Year Final Research Report
Pharmacokinetics of landiolol in patients undergoing vascular surgery
| Project/Area Number |
23791680
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 麻酔学 |
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| Research Abstract |
Measured concentrations of landiolol were similar to the predicted concentrations of landiolol calculated using parameters from healthy volunteer. There was no large difference in the pharmacokinetic parameters of landiolol in healthy volunteers and patients undergoing vascular surgery. High sensitivity to landiolol in high-risk patients are thought to be contributed to by pharmacodynamics rather than pharmacokinetics.
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