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2012 Fiscal Year Final Research Report

Elucidation of the role of aquaporin 1 in CRPS

Research Project

  • PDF
Project/Area Number 23791689
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNiigata University

Principal Investigator

PETRENKO Andrey  新潟大学, 医歯学系, 助教 (30397153)

Project Period (FY) 2011 – 2012
Keywordsアクアポリン1 / CRPS / 虚血後慢性疼痛モデル
Research Abstract

AQP1 water channel is involved in both edema formation and pain. Edema and pain are hallmarks of CRPS I, a debilitating chronic pain condition that can develop in 10-20% of patients following fractures or other similar injuries. This study was undertaken to find out if AQP1 protein is involved in the mechanism of CRPS. We investigated the role of AQP1 in the development of edema and hypersensitivity in CPIP model. A pharmacological approach that used acetazolamide, an inhibitor of AQP1 function was used. Mice that underwent CPIP procedure were given acetazolamide beginning the day before the injury and continuing for the observation period of 28 days. As we showed, acetazolamide had no effect on the extent of edema and the time course of its resolution following the reperfusion. Also, no differences in pain thresholds were found in mice receiving AQP1 inhibitor in mechanical and thermal sensory assays performed during 28-day postreperfusion period. Our results indicate that AQP is unlikely to be involved in the edema formation following ischemia-reperfusion injury. It is also unlikely to be involved in the development of pain hypersensitivity following such injury. They also suggest that targets other than AQP1 should be looked for pharmacological management of CRPS.

  • Research Products

    (4 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Increased brain monoaminergic tone after the NMDA receptor GluN2A subunit gene knockout is responsible for resistance to the hypnotic effect of nitrous oxide2013

    • Author(s)
      Petrenko Andrey ほか
    • Journal Title

      Eur J Pharmacol

      Volume: 698 Pages: 200-205

    • Peer Reviewed
  • [Journal Article] effects during and hyperalgesia after prolonged remifentanil administration in mice2013

    • Author(s)
      Ishii Hideaki、Petrenko Andrey ほか
    • Journal Title

      Mol Pain

      Volume: 9

    • DOI

      doi:10.1186/1744-8069-9-11

    • Peer Reviewed
  • [Presentation] 虚血また神経損傷によるCRPSの動物モデルの作成について2012

    • Author(s)
      Petrenko Andrey
    • Organizer
      第76回新潟麻酔懇話会/第55回新潟ショックと蘇生・集中治療研究会
    • Place of Presentation
      新潟
    • Year and Date
      2012-12-01
  • [Presentation] 虚血によるCRPSの動物モデルの作成について2012

    • Author(s)
      Petrenko Andrey
    • Organizer
      第75回新潟麻酔懇話会/第54回新潟ショックと蘇生・集中治療研究会
    • Place of Presentation
      新潟
    • Year and Date
      2012-06-02

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Published: 2014-09-25   Modified: 2021-04-07  

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