2012 Fiscal Year Final Research Report
Molecular biological analysis about the effect of general anesthetics on the induction of erythropoietin in the brain
| Project/Area Number |
23791703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto University |
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Principal Investigator |
TANAKA Tomoharu 京都大学, 医学(系)研究科(研究院), 助教 (10402893)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 麻酔学 / 脳内エリスロポエチン / 低酸素 |
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| Research Abstract |
Erythropoietin is endogenously expressed in the central nervous system (CNS). EPO in the CNS, mainly produced in astrocytes. We investigated the effect of general anesthetics on EPO expression in the mouse brain and primary cultured astrocytes.We found the common inhibitory effect of the general anesthetics against hypoxia-induced EPO upregulation in the mouse brain through a direct effect on astrocytes.
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