2013 Fiscal Year Final Research Report
Effects of anesthetics on airway hypersensitivity
| Project/Area Number |
23791714
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 気道リモデリング / 麻酔薬 / 喘息 |
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| Research Abstract |
We investigated the contractile response of tracheal smooth muscle of asthma model rats. Three weeks of additional sensitization period could induce airway remodeling in our asthma model rats. Inhalation of sevoflurane during sensitization period attenuated the increase of goblet cells in the airway remodeling. It was difficult to observe functional change in the contractile response with this model. On the other hand, we applied continuous electrical field stimulation (c-EFS) or continuous electrical stimulation (c- ES) of low frequency to the vagal nerve of normal rats in vitro and in vivo to determine the role of cholinergic nerve activation in inducing airway constriction. The contractile response of the tracheal ring to c-EFS was potentiated by neostigmine. Maximum airway pressure was increased by c-ES of vagal nerve, and was potentiated by neostigmine. These results suggest that the increased activity of the cholinergic nerve is involved in asthma attack.
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Research Products
(2 results)
