2013 Fiscal Year Final Research Report
Development of a new treatment for renal ischemic-reperfusion injury using ETS-GS, a novel vitamin E
| Project/Area Number |
23791716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
KUSAKA Junya 大分大学, 医学部, 客員研究員 (00567951)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腎機能障害 / ビタミンE / グルタチオン / タウリン / 酸化ストレス / 急性障害 |
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| Research Abstract |
We investigated whether ETS-GS, a novel vitamin E derivative, had therapeutic effect against renal ischemic-reperfusion injury in rat model. In this study, we found that ETS-GS improved the survival retes, renal disfunction after renal ischemic-reperfusion, which was also demonstrated by histological evaluation. In addition, our results indicated that the mechanism of improvement effect against renal ischemic-reperfusion injury may be involved in antioxidant effect by ETS-GS.
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