2012 Fiscal Year Final Research Report

Neuroprotection using hydrogen sulfide donors : in the mice primary cultured neurons

Research Project

Project/Area Number	23791718
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of the Ryukyus
Principal Investigator	KAMIZATO Kota 琉球大学, 医学部附属病院, 助教 (10554454)
Project Period (FY)	2011 – 2012
Keywords	神経保護 / 硫化水素 / 対麻痺
Research Abstract	Paraplegia is a severe complication after the surgery of thoracic aorta anyrism. But the mechanism is unknown. We performed a study on mechanism of the neuroprotection with hydrogen sulfide after spinal cord ischemia, using the mice primary cultured neurons. We used sodium sulphide and GYY4137 as a hydrogen sulfide donor. However, the effect of neuroprotection for cultured neurons was weak. We seek the protein signals in the neurons with hydrogen sulfide attaching (sodium sulphide and GYY4137) by DNA micro array. However, no significant change was confirmed by DNA micro array.

(1 results)