2013 Fiscal Year Final Research Report
Association of genetic polymorphisms of the GABRB3 gene with the concentration of propofol at loss of consciousness
| Project/Area Number |
23791719
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NAWA Yuko 札幌医科大学, 医学部, 助教 (90586794)
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| Research Collaborator |
SUGINO Shigekazu 札幌医科大学, 医学部, 助教 (00423765)
HAYASE Tomo 札幌医科大学, 医学部, 助教 (20579007)
SATO Michiko 札幌医科大学, 医学部, 研究生
TACHIBANA Shun-suke 札幌医科大学, 医学部, 大学院生
MORIYA Hiroyuki 北海道薬科大学, 薬学部, 助教 (00337049)
YAMAKAGE Michiaki 札幌医科大学, 医学部, 教授 (70285005)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子 / 静脈麻酔薬 / GABA受容体 / 遺伝子多型 / 入眠 |
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| Research Abstract |
We hypothesized that the genetic polymorphisms in the GABRB3 gene are associated with the individual differences in concentration of propofol at loss of consciousness. We examined the genotypes of single nucleotide polymorphisms (SNPs) in the coding sequence of the GABRB3 gene. However, none of the genotyped SNPs were associated with the concentration at loss of consciousness. These results raised the possibility that we need to change the experimental design or to increase the size of the cohort.
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