Adhesion protect by an angiotensin type 1 receptor antagonist

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791723
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: YOSHIMURA Seiko 和歌山県立医科大学, 医学部, 助教 (40468286)
• Project Period (FY): 2011 – 2012
• Keywords: カンデサルタン / PAI-1 / 糖尿病 / 開腹術 / 癒着

Research Abstract

Adhesion formations are important causes of intestinal obstruction and can lead to infertility in women. This study indicated that angiotensin type 1receptorantagonist, candesartan, can reduce plasminogen activator inhibitor-1 mRNA expression using experimental model of peritoneal adhesions.

Research Products

• [Journal Article] Delayed hemopneumothorax resulting from a ventriculoperitoneal shunt procedure. (2011)
  • Author(s): Hirayama M, Kinoshita H, Inoue M,Kawashima K, Yoshimura S:
  • Journal Title: Minerva Anestesiol Volume: 77 Pages: 938
• [Presentation] Ultrasound-guided Lateral Approach of the Infraclavicular Axillary Vein Catheterization May Have a Risk of Brachial Plexus Injury (2011)
  • Author(s): Seiko Yoshimura, M.D., Keisuke Fujii, M.D., Masanori Haba, M.D., Takaaki Negoro, M.D., Koji Ogawa, M.D
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 20111000