2012 Fiscal Year Final Research Report
The crosstalk pathway between macrophages and T-lymphocytes involves in neuropathic pain
| Project/Area Number |
23791724
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KOBAYASHI Yuka 和歌山県立医科大学, 医学部, 助教 (20511562)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経障害性疼痛 / 神経炎症 / マクロファージ / T 細胞 / GITR / GITRL |
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| Research Abstract |
The activated immune cells-induced peripheral neuroinflammation contributes to the pathogenesis of neuropathic pain. We investigated the involvement of crosstalk between macrophages and T cells in neuropathic pain. Macrophages and T -lymphocytes infiltrated in the injured sciatic nerve, and they expressed GITRL and GITR which are co-stimulatory molecules. The inhibition of crosstalk alleviated nerve injury-induced neuropathic pain. Threfore, the regulation of neuroinflammtion through a crosstalk between macrophages and T -lymphocytes cells plays a crucial role in neuropathic pain.
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