2013 Fiscal Year Final Research Report
The mechanism of HMGB1 in the pathogenesis of septic encephalopathy
| Project/Area Number |
23791728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳・神経 / 敗血症 / HMGB1 / 睡眠・覚醒 / MCH / 記憶 / 集中治療 |
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| Research Abstract |
We demonstrated that intracerebroventricular (icv) injection of HMGB1(High mobility group box 1) reduced awakening period, and increased the non-rapid eye movement episode time.We also demonstrated that icv injection of melanin-concentrating hormone(MCH) increased hippocampal acetylcholine release in both HMGB1 (pre-treatment) group and normal saline(pre-treatment) group. Icv injection of HMGB1 did not reduce the hippocampus acetylcholine release, and had no effect on hippocampal acetylcholine release after icv injection of MCH.
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