Neonatal desflurane exposure induces more robust neuroapoptosis than do isoflurane and sevoflurane and impairs working memory.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23791734
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: National Defense Medical College
• Principal Investigator: KODAMA Mitsuyoshi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 助教 (00597528)
• Co-Investigator(Kenkyū-buntansha): 佐藤 泰司 防衛医科大学校, 麻酔学講座 (10505267)
• Co-Investigator(Renkei-kenkyūsha): 風間 富栄 防衛医科大学校, 麻酔学講座 (40158837)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 麻酔薬 / 発達期脳神経 / 毒性

Outline of Final Research Achievements

1.In an animal model, neonatal desflurane exposure induced more neuroapoptosis than did sevoflurane or isoflurane and impaired working memory, suggesting that desflurane is more neurotoxic than sevoflurane or isoflurane.2.Inhalation of hydrogen gas robustly decreased neuronal apoptosis and subsequent cognitive impairments caused by neonatal exposure to sevoflurane.3.In an animal model, sevoflurane exposure in the developing brain caused serious impairment of maternal behaviors when fostering their pups, suggesting pervasive impairment of brain functions including innate behavior essential to species survival.

Free Research Field

麻酔学