2012 Fiscal Year Final Research Report
The effects of statin on prostate cancer progression via miRNA
| Project/Area Number |
23791741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腫瘍学 |
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| Research Abstract |
Statins have been being studied for their proapoptic and antimetastatic effects. However, the exact mechanisms of their anticancer action are still unclear. In this study, we identified miRNAs affected by treatment of statins, and mRNAs, targeted by the identified miRNAs, which are concerned with progression of prostate cancer. In PC-3 cells, theexpressions of miR-210 and miR-375 were up-regulated by simvastatin. Moreover, INSIG1, which is a target of miR-210 and down-regulated by simvastatin, seemed to play a role in the antitumoral effects of statin.
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Research Products
(1 results)
